Kisspeptin-10 10mg – Research Peptide

Research Area: Reproductive Endocrinology & Molecular Research

Product Description

Kisspeptin-10 is a synthetic decapeptide derived from the kisspeptin family and corresponds to residues 145–154 of the human kisspeptin precursor. It functions as an endogenous ligand of the G-protein-coupled receptor KISS1R (GPR54) and has been extensively investigated in studies of reproductive endocrinology, neuroendocrine signaling, and the hypothalamic–pituitary–gonadal (HPG) axis.

Kisspeptin signaling is closely associated with the regulation of gonadotropin-releasing hormone (GnRH) secretion. Consequently, Kisspeptin-10 provides a defined peptide model for laboratory studies examining KISS1R activation, intracellular signaling, neuroendocrine regulation, and reproductive biology.

Kisspeptin-10 is supplied as a lyophilized powder for qualified laboratory research. The material is intended exclusively for in vitro, analytical, and non-clinical research applications.

Product Designation Note

Kisspeptin-10, also known as Metastin (145–154), is a 10-amino-acid fragment derived from the C-terminal region of kisspeptin. It represents one of the biologically active kisspeptin fragments used in experimental studies of KISS1R-mediated signaling.

The product should be distinguished from longer kisspeptin isoforms and other synthetic kisspeptin analogs or modified derivatives.

Research Applications

Kisspeptin-10 may be used as a research material in studies involving:

• KISS1R/GPR54 receptor signaling
• Reproductive endocrinology
• Hypothalamic–pituitary–gonadal axis research
• GnRH-associated signaling
• Neuroendocrine regulation
• Peptide–receptor interactions
• Intracellular signaling pathways
• Kisspeptin biology and reproductive physiology
• Peptide structure and stability studies
• Analytical characterization and identification
• Assay development and method validation

Research Background

The kisspeptin/KISS1R system is an important signaling pathway in reproductive neuroendocrinology. Kisspeptin-producing neurons provide regulatory input to GnRH neurons, linking kisspeptin signaling with downstream reproductive endocrine pathways.

Kisspeptin-10 has been used extensively as an experimental peptide for investigating KISS1R activation and the cellular mechanisms associated with kisspeptin signaling. Research has examined receptor binding, signal transduction, and the relationship between kisspeptin activity and GnRH-associated neuroendocrine responses.

KISS1R & Molecular Signaling Research

Kisspeptin-10 interacts with KISS1R/GPR54, a G-protein-coupled receptor expressed in tissues associated with reproductive neuroendocrine regulation. Activation of this receptor provides a model for studying downstream intracellular signaling and communication between kisspeptin-producing neurons and reproductive endocrine pathways.

This makes Kisspeptin-10 particularly useful in controlled laboratory studies investigating peptide–receptor interactions, receptor activation, signal transduction, and neuroendocrine communication.

Reproductive Endocrinology Research

The kisspeptin/KISS1R pathway has been extensively studied in relation to the HPG axis. Experimental research has demonstrated that kisspeptin signaling can regulate GnRH-associated activity, making the pathway an important subject in reproductive biology and endocrine research.

Kisspeptin-10 therefore provides a defined molecular tool for investigating the mechanisms connecting neuropeptide signaling with reproductive endocrine pathways under controlled experimental conditions.

Product Specifications

Storage and Handling

• Store the lyophilized material according to validated laboratory procedures and supplier specifications.
• Protect from excessive heat, moisture, and direct light.
• Keep the container sealed when not in use.
• Any reconstitution or preparation should be performed according to an appropriate validated laboratory protocol.
• Avoid unnecessary repeated freeze–thaw cycles where applicable.
• Handle using appropriate laboratory practices for synthetic peptide research materials.

Compliance Notice

FOR RESEARCH USE ONLY.

Kisspeptin-10 is supplied as a research material for qualified laboratory use and is not intended for human or veterinary administration. The biological effects described above represent findings from experimental and research studies and should not be interpreted as established therapeutic claims.