KPV 10mg – Research Peptide

Research Area: Cell Biology & Inflammation Research

Product Description

KPV (Lys-Pro-Val) is a synthetic tripeptide composed of lysine, proline, and valine. It corresponds to the C-terminal residues 11–13 of alpha-melanocyte-stimulating hormone (α-MSH) and is also identified as alpha-MSH(11–13). KPV has been investigated primarily in preclinical models of inflammatory signaling, cellular responses, and tissue inflammation.

Due to its small three-amino-acid structure, KPV provides a defined peptide fragment for laboratory studies examining peptide-mediated cellular responses and inflammation-related pathways. Research has investigated its relationship with NF-κB signaling, cytokine-associated responses, and inflammatory processes in gastrointestinal and other tissue models.

KPV is supplied as a lyophilized powder for qualified laboratory research. The material is intended exclusively for in vitro, analytical, and non-clinical research applications.

Product Designation Note

KPV is the Lys-Pro-Val tripeptide, corresponding to residues 11–13 of α-MSH. It should be distinguished from the complete α-MSH peptide and from modified KPV analogs, including N-terminally acetylated or C-terminally amidated derivatives. The specifications below refer to the parent KPV free-acid compound.

Research Applications

KPV may be used as a research material in studies involving:

• NF-κB-related cellular signaling
• Inflammation and cytokine-associated pathways
• Peptide–cell interactions
• Gastrointestinal inflammation models
• Cellular and tissue inflammatory responses
• Alpha-MSH-derived peptide biology
• Peptide structure and stability studies
• Analytical characterization and identification
• Assay development and method validation
• Comparative studies of peptide fragments and analogs

Research Background

KPV has been investigated as a C-terminal fragment of α-MSH in experimental inflammation research. Early studies identified α-MSH(11–13) as a biologically active tripeptide fragment, while subsequent research examined its effects in experimental inflammatory models.

Research has particularly focused on inflammatory signaling and NF-κB-associated mechanisms. Studies in experimental intestinal inflammation have evaluated KPV in models of colitis, while other research has investigated its effects in experimental inflammatory responses involving the brain and other tissues.

The available evidence is predominantly preclinical and should not be interpreted as evidence of established clinical efficacy.

Product Specifications

The molecular formula, molecular weight, CAS number, and PubChem identification correspond to the parent KPV free-acid compound.

Storage and Handling

• Store the lyophilized material according to validated laboratory procedures and supplier specifications.
• Protect from excessive moisture, heat, and direct light.
• Keep the container sealed when not in use.
• Any reconstitution or preparation should be performed according to an appropriate validated laboratory protocol.
• Avoid unnecessary repeated freeze–thaw cycles where applicable.
• Handle using appropriate laboratory practices for synthetic peptide research materials.

Compliance Notice

FOR RESEARCH USE ONLY.

KPV is supplied as a research material for qualified laboratory use and is not intended for human or veterinary administration. The research findings described above are primarily derived from preclinical and experimental models and should not be interpreted as established therapeutic claims.